{"id":25301,"date":"2026-11-05T12:47:51","date_gmt":"2026-11-05T12:47:51","guid":{"rendered":"https:\/\/aeprilclinics.nl\/rejuran-vs-polyphil-which-one-do-we-use-and-why\/"},"modified":"2026-11-05T12:49:47","modified_gmt":"2026-11-05T12:49:47","slug":"rejuran-vs-polyphil-which-one-do-we-use-and-why","status":"publish","type":"post","link":"https:\/\/aeprilclinics.nl\/en\/2026\/11\/05\/rejuran-vs-polyphil-which-one-do-we-use-and-why\/","title":{"rendered":"Rejuran vs. PolyPhil: Which One Do We Use and Why?"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Polynucleotides, also known as Salmon DNA, have become one of the most sought-after treatments in recent years for skin that has started to look thinner, drier, or more tired. If you look into them further, you\u2019ll quickly come across two names: Rejuran and PolyPhil. Both are polynucleotide treatments, but they are not the same products. In this blog, we\u2019ll explain what they have in common, how they differ, and how our doctors at Aepril Clinics make their recommendations.<\/strong><\/p>\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<div class=\"wp-block-media-text has-media-on-the-right is-stacked-on-mobile is-image-fill-element\"><div class=\"wp-block-media-text__content\">\n<h5 class=\"wp-block-heading\">The active ingredient<\/h5>\n\n\n\n<h2 class=\"wp-block-heading\">What are polynucleotides?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Polynucleotides are purified DNA fragments, usually derived from salmon or trout. They are administered into the skin via small injections to support the skin\u2019s natural repair processes. This includes collagen and elastin production, hydration, and the skin\u2019s overall structure.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Polynucleotides do not add volume directly, as fillers do.<\/strong> They do not change the shape of your face, but rather focus on improving skin quality. The effects and scientific basis of these DNA fragments are discussed in greater detail in our article on <a href=\"https:\/\/aeprilclinics.nl\/en\/2026\/03\/02\/what-are-polynucleotides-and-do-they-really-work\/\">what polynucleotides are and how they work<\/a>.<\/p>\n<\/div><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"683\" height=\"1024\" src=\"https:\/\/aeprilclinics.nl\/wp-content\/uploads\/2026\/03\/Polynucleotiden-Aepril-Clinics-683x1024.png\" alt=\"\" class=\"wp-image-5517 size-full\" style=\"object-position:50% 50%\" srcset=\"https:\/\/aeprilclinics.nl\/wp-content\/uploads\/2026\/03\/Polynucleotiden-Aepril-Clinics-683x1024.png 683w, https:\/\/aeprilclinics.nl\/wp-content\/uploads\/2026\/03\/Polynucleotiden-Aepril-Clinics-200x300.png 200w, https:\/\/aeprilclinics.nl\/wp-content\/uploads\/2026\/03\/Polynucleotiden-Aepril-Clinics-768x1152.png 768w, https:\/\/aeprilclinics.nl\/wp-content\/uploads\/2026\/03\/Polynucleotiden-Aepril-Clinics-180x270.png 180w, https:\/\/aeprilclinics.nl\/wp-content\/uploads\/2026\/03\/Polynucleotiden-Aepril-Clinics.png 1024w\" sizes=\"auto, (max-width: 683px) 100vw, 683px\" \/><\/figure><\/div>\n\n<div style=\"height:35px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<div class=\"wp-block-media-text is-stacked-on-mobile is-image-fill-element\"><figure class=\"wp-block-media-text__media\"><img decoding=\"async\" src=\"https:\/\/aeprilclinics.nl\/wp-content\/uploads\/2025\/01\/BN4A0034-1-1-scaled.jpg\" alt=\"Injection Treatment by a Doctor at Aepril Clinics\" style=\"object-position:50% 50%\"\/><\/figure><div class=\"wp-block-media-text__content\">\n<h5 class=\"wp-block-heading\">Rejuran<\/h5>\n\n\n\n<h2 class=\"wp-block-heading\">Rejuran: The Most Well-Known Polynucleotide<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Rejuran is considered one of the first well-known polynucleotide products for skin improvement and has been used as a skin booster since 2014. At Aepril Clinics, we use Rejuran by Vivacy, which comes in two variants:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong><a href=\"https:\/\/aeprilclinics.nl\/en\/skin-improvement\/rejuran-i-polynucleotide-treatment\/\">Rejuran I<\/a>:<\/strong> specifically designed for the thin, delicate skin around the eyes. Think of fine lines, crepey skin, and a tired appearance.<\/li>\n\n\n\n<li><strong><a href=\"https:\/\/aeprilclinics.nl\/en\/skin-improvement\/rejuran-healer-polynucleotide-treatment\/\">Rejuran Healer<\/a>:<\/strong> designed to improve the skin on the face, with a focus on hydration, elasticity, and smoother skin.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">A course of treatment usually consists of 2 to 3 sessions. Each session lasts about 10 to 20 minutes, and the results remain visible for an average of 6 to 12 months, depending on your skin and lifestyle. The exact duration varies from person to person and also depends on the number of treatments.<\/p>\n<\/div><\/div>\n\n<div style=\"height:35px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<div class=\"wp-block-media-text has-media-on-the-right is-stacked-on-mobile is-image-fill-element\"><div class=\"wp-block-media-text__content\">\n<h5 class=\"wp-block-heading\">PolyPhil<\/h5>\n\n\n\n<h2 class=\"wp-block-heading\">PolyPhil: Face, Eyes, and Hair<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">PolyPhil is also a polynucleotide treatment using salmon DNA. At Aepril Clinics, we use three variants, tailored to the treatment area: PolyPhil Face for facial skin, PolyPhil Eyes for the skin around the eyes, and PolyPhil Hair for hair and the scalp.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">With PolyPhil, too, the results develop gradually. You won\u2019t see an immediate change like you would with a filler, but in the weeks following the treatment, your skin may feel smoother, better hydrated, and firmer. On average, the effect lasts 6 to 12 months. <a href=\"https:\/\/aeprilclinics.nl\/en\/2026\/08\/31\/polyphil-face-salmon-dna-for-your-face\/\">PolyPhil Face, specifically designed for the face<\/a>, is used primarily to improve skin quality without adding extra volume.<\/p>\n<\/div><figure class=\"wp-block-media-text__media\"><img decoding=\"async\" src=\"https:\/\/aeprilclinics.nl\/wp-content\/uploads\/2026\/04\/BN4A9229-scaled.jpg\" alt=\"Cosmetic skin-improvement treatment in a treatment room at Aepril Clinics\" style=\"object-position:50% 50%\"\/><\/figure><\/div>\n\n<div style=\"height:35px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<h5 class=\"wp-block-heading\">The Comparison<\/h5>\n\n<h2 class=\"wp-block-heading\">Rejuran or PolyPhil: What\u2019s the Difference?<\/h2>\n\n<p class=\"wp-block-paragraph\">Both treatments are based on polynucleotides and share the same goal: to improve the skin from within without directly adding volume. That\u2019s why, on paper, they appear very similar.<\/p>\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th><\/th><th>Rejuran<\/th><th>PolyPhil<\/th><\/tr><\/thead><tbody><tr><td><strong>Active ingredient<\/strong><\/td><td>Polynucleotides (Salmon DNA)<\/td><td>Polynucleotides (Salmon DNA)<\/td><\/tr><tr><td><strong>Variants available at Aepril<\/strong><\/td><td>Rejuran I (eyes) and Rejuran Healer (face)<\/td><td>PolyPhil Face, Eyes, and Hair<\/td><\/tr><tr><td><strong>Adding volume<\/strong><\/td><td>No immediate volumizing effect like with fillers<\/td><td>No immediate volumizing effect like with fillers<\/td><\/tr><tr><td><strong>Average duration of the effect<\/strong><\/td><td>6 to 12 months<\/td><td>6 to 12 months<\/td><\/tr><tr><td><strong>Intended for<\/strong><\/td><td>Skin quality, hydration, and elasticity<\/td><td>Skin quality, hydration, and elasticity, with a separate formula for hair and scalp<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<p class=\"wp-block-paragraph\">As far as is known, there are no major studies that directly compare Rejuran and PolyPhil. The differences lie primarily in the products themselves\u2014such as their composition, concentration, and the way the gel is manufactured\u2014and in the variants available for a specific area.<\/p>\n\n<p class=\"wp-block-paragraph\">In the scientific literature, a distinction is also made between polynucleotides (PN, longer chains) and PDRN (shorter fragments). Brochures and packaging do not always clearly explain exactly what you are getting. Therefore, ask your doctor which formulation is used and why it is suitable for your skin.<\/p>\n\n<div style=\"height:35px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<div class=\"wp-block-media-text is-stacked-on-mobile is-image-fill-element\"><figure class=\"wp-block-media-text__media\"><img decoding=\"async\" src=\"https:\/\/aeprilclinics.nl\/wp-content\/uploads\/2025\/01\/BN4A8716-scaled.jpg\" alt=\"Personal consultation at Aepril Clinics regarding the choice between Rejuran and PolyPhil\" style=\"object-position:50% 50%\"\/><\/figure><div class=\"wp-block-media-text__content\">\n<h5 class=\"wp-block-heading\">Personalized treatment advice<\/h5>\n\n\n\n<h2 class=\"wp-block-heading\">Which one do we use, and why?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">At Aepril Clinics, we work with both product lines. We choose based on what your skin needs. During the consultation, the doctor will assess:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>The treatment area:<\/strong> the skin around the eyes requires a different approach than the skin on the cheeks.<\/li>\n\n\n\n<li><strong>Skin quality:<\/strong> the thickness, firmness, and overall condition of your skin.<\/li>\n\n\n\n<li><strong>Previous treatments:<\/strong> how your skin has responded to them.<\/li>\n\n\n\n<li><strong>Your goals and schedule:<\/strong> the results you\u2019re looking for and the treatment plan that best suits them.<\/li>\n\n\n\n<li><strong>Product information:<\/strong> the composition, origin, and suitability for the selected area.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">This way, you\u2019ll receive treatment recommendations tailored to your skin and preferences. Sometimes we recommend a different type of skin enhancement treatment, such as <a href=\"https:\/\/aeprilclinics.nl\/en\/skin-improvement\/profhilo-treatment\/\">Profhilo<\/a> or <a href=\"https:\/\/aeprilclinics.nl\/en\/skin-improvement\/belotero-revive-treatment-2\/\">Belotero Revive<\/a>. The doctor will explain the differences and help you make a decision.<\/p>\n<\/div><\/div>\n\n<div style=\"height:35px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<div class=\"wp-block-media-text has-media-on-the-right is-stacked-on-mobile is-image-fill-element\"><div class=\"wp-block-media-text__content\">\n<h5 class=\"wp-block-heading\">Eligibility<\/h5>\n\n\n\n<h2 class=\"wp-block-heading\">Who is a good candidate for a polynucleotide treatment?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Polynucleotide treatment is primarily aimed at improving skin quality. You may want to consider this treatment if:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Your skin feels thinner, drier, or less supple.<\/li>\n\n\n\n<li>You notice fine lines or crepey skin, for example under the eyes.<\/li>\n\n\n\n<li>You want to improve your skin without visible added volume.<\/li>\n\n\n\n<li>You\u2019re looking for a subtle result that develops gradually.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Not every type of dark circles has the same cause. If they\u2019re caused by thin skin, a polynucleotide treatment may help. If they\u2019re caused by pigmentation or shadows resulting from volume loss, a different treatment may be more appropriate. The doctor will assess this during the consultation.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">When is the treatment not recommended?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">A polynucleotide treatment is not recommended during pregnancy or while breastfeeding, and is not suitable if you have an active skin infection at the treatment site or a known allergy to the product. Do you have a fish allergy? Always mention this in advance so the doctor can carefully assess the composition and suitability of the treatment.<\/p>\n<\/div><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"768\" src=\"https:\/\/aeprilclinics.nl\/wp-content\/uploads\/2026\/05\/Profhilo-stralende-huid-1024x768.png\" alt=\"\" class=\"wp-image-6062 size-full\" style=\"object-position:50% 50%\" srcset=\"https:\/\/aeprilclinics.nl\/wp-content\/uploads\/2026\/05\/Profhilo-stralende-huid-1024x768.png 1024w, https:\/\/aeprilclinics.nl\/wp-content\/uploads\/2026\/05\/Profhilo-stralende-huid-300x225.png 300w, https:\/\/aeprilclinics.nl\/wp-content\/uploads\/2026\/05\/Profhilo-stralende-huid-768x576.png 768w, https:\/\/aeprilclinics.nl\/wp-content\/uploads\/2026\/05\/Profhilo-stralende-huid-360x270.png 360w, https:\/\/aeprilclinics.nl\/wp-content\/uploads\/2026\/05\/Profhilo-stralende-huid.png 1448w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n<div style=\"height:35px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<div class=\"wp-block-media-text is-stacked-on-mobile is-image-fill-element\"><figure class=\"wp-block-media-text__media\"><img decoding=\"async\" src=\"https:\/\/aeprilclinics.nl\/wp-content\/uploads\/2025\/01\/BN4A8655-scaled.jpg\" alt=\"Medical Supervision for a Skin-Improving Injection Treatment\" style=\"object-position:50% 50%\"\/><\/figure><div class=\"wp-block-media-text__content\">\n<h5 class=\"wp-block-heading\">Results and Aftercare<\/h5>\n\n\n\n<h2 class=\"wp-block-heading\">What can you expect after the treatment?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Immediately after treatment, redness, swelling, small bumps, tenderness, or bruising may be visible at the injection sites. The bumps usually subside on their own. The results develop gradually: in the weeks following treatment, the skin may become smoother and more resilient. With some treatments, the first noticeable results become visible after about 2 to 4 weeks. The full results depend in part on the number of sessions.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What should you keep in mind after treatment?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">For a full recovery, we recommend the following aftercare:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Touch the treated area as little as possible for the first 24 hours.<\/li>\n\n\n\n<li>Do not apply makeup or cream to the injection sites for the first 24 hours.<\/li>\n\n\n\n<li>Avoid strenuous physical activity for the first 24 hours.<\/li>\n\n\n\n<li>Postpone saunas, tanning beds, and other cosmetic treatments on the treated area for two weeks.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Always follow the post-treatment care instructions provided by your treating physician. After your procedure, you can schedule a free follow-up appointment at Aepril Clinics. If you experience any persistent or unexpected symptoms, please contact the clinic.<\/p>\n<\/div><\/div>\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<div class=\"wp-block-media-text has-media-on-the-right is-stacked-on-mobile is-image-fill-element\"><div class=\"wp-block-media-text__content\">\n<h5 class=\"wp-block-heading\">Frequently Asked Questions<\/h5>\n\n\n\n<h2 class=\"wp-block-heading\">Frequently Asked Questions About Rejuran and PolyPhil<\/h2>\n\n\n\n<div class=\"schema-faq wp-block-yoast-faq-block\"><div class=\"schema-faq-section\" id=\"faq-rejuran-polyphil-1\"><strong class=\"schema-faq-question\">Is Rejuran better than PolyPhil?<\/strong> <p class=\"schema-faq-answer\">Not necessarily. Both products contain polynucleotides and are designed to improve skin quality. Which treatment is best for you depends on the treatment area, your skin condition, and the product\u2019s composition. During the consultation, the doctor will determine which option is appropriate.<\/p> <\/div> <div class=\"schema-faq-section\" id=\"faq-rejuran-polyphil-2\"><strong class=\"schema-faq-question\">What is the difference between Rejuran and PolyPhil?<\/strong> <p class=\"schema-faq-answer\">Rejuran and PolyPhil are both treatments based on polynucleotides. The differences include the product formulation and the available variants. Aepril Clinics uses Rejuran I and Healer for the eyes and face, and PolyPhil Face, Eyes, and Hair for the face, eye area, and scalp.<\/p> <\/div> <div class=\"schema-faq-section\" id=\"faq-rejuran-polyphil-3\"><strong class=\"schema-faq-question\">How long do the results of Rejuran or PolyPhil last?<\/strong> <p class=\"schema-faq-answer\">According to Aepril Clinics\u2019 treatment information, the results remain visible for an average of 6 to 12 months after a course of treatment. The exact duration of the results varies from person to person and depends, among other things, on skin condition, lifestyle, and the number of treatments. Follow-up treatments may be necessary.<\/p> <\/div> <div class=\"schema-faq-section\" id=\"faq-rejuran-polyphil-4\"><strong class=\"schema-faq-question\">Are Rejuran and PolyPhil fillers?<\/strong> <p class=\"schema-faq-answer\">No, Rejuran and PolyPhil are polynucleotide treatments designed to improve skin quality. They do not provide the immediate volumizing effect of a hyaluronic acid filler. The treatment supports processes in the skin that can contribute to hydration, elasticity, and a smoother skin texture.<\/p> <\/div> <\/div>\n<\/div><figure class=\"wp-block-media-text__media\"><img decoding=\"async\" src=\"https:\/\/aeprilclinics.nl\/wp-content\/uploads\/2025\/11\/IMG_8565-scaled.jpg\" alt=\"Consultation on Polynucleotide Treatments at Aepril Clinics\" style=\"object-position:50% 50%\"\/><\/figure><\/div>\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<div class=\"wp-block-media-text is-stacked-on-mobile is-image-fill-element\"><figure class=\"wp-block-media-text__media\"><img decoding=\"async\" src=\"https:\/\/aeprilclinics.nl\/wp-content\/uploads\/2025\/01\/BN4A8332-Verbeterd-NR-scaled.jpg\" alt=\"Consultation at Aepril Clinics for personalized treatment advice\" style=\"object-position:50% 50%\"\/><\/figure><div class=\"wp-block-media-text__content\">\n<h5 class=\"wp-block-heading\">Rates<\/h5>\n\n\n\n<h2 class=\"wp-block-heading\">How much do Rejuran and PolyPhil cost?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The cost of Rejuran and PolyPhil depends on the chosen option, the treatment area, and the number of sessions. You can find the current prices for both treatments on our <a href=\"https:\/\/aeprilclinics.nl\/en\/rates\/\">pricing page<\/a>. During your consultation, we\u2019ll discuss which treatment plan is right for your skin and the associated costs.<\/p>\n<\/div><\/div>\n\n<div style=\"height:35px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<style>.medical-review {\n        display: grid;\n        grid-template-columns: minmax(210px, 260px) minmax(0, 1fr);\n        gap: clamp(32px, 5vw, 72px);\n        align-items: start;\n        margin: 48px 0;\n        padding: clamp(32px, 5vw, 64px);\n        background: #f7f3ef;\n        border-radius: 32px;\n        color: #252321;\n    }\n\n    .medical-review__image {\n        width: 100%;\n        max-width: 260px;\n        margin: 0;\n    }\n\n    .medical-review__photo {\n        position: relative;\n        width: 100%;\n        aspect-ratio: 4 \/ 5;\n        overflow: hidden;\n        background: #eee9e4;\n        border-radius: 100px 100px 30px 30px;\n    }\n\n    .medical-review__photo img {\n        position: absolute !important;\n        inset: 0;\n    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1fr;\n            gap: 20px;\n        }\n\n        .medical-review__links {\n            flex-direction: column;\n            align-items: stretch;\n        }\n\n        .medical-review__button {\n            width: 100%;\n        }\n\n        .medical-review__text-link {\n            display: inline-block;\n        }\n    }\n<\/style><aside class=\"medical-review\" aria-labelledby=\"medical-review-title\"><figure class=\"medical-review__image\"><div class=\"medical-review__photo\"><img decoding=\"async\" src=\"https:\/\/aeprilclinics.nl\/wp-content\/uploads\/2026\/07\/BN4A8634-scaled-1.jpg\" alt=\"Drs. Elnaz Alagha, BIG-geregistreerd cosmetisch arts en medisch directrice van Aepril Clinics\" loading=\"lazy\"\/><\/div><figcaption class=\"medical-review__identity\"><span class=\"medical-review__name\">drs. Elnaz Alagha\n            <\/span><span class=\"medical-review__role\">BIG-geregistreerd cosmetisch arts<br\/>Eigenaresse en medisch directrice\n            <\/span><\/figcaption><blockquote class=\"medical-review__quote\">\u201cSoms is geen behandeling de beste behandeling.\u201d\n            <cite>\u2014 drs. Elnaz Alagha<\/cite><\/blockquote><\/figure><div class=\"medical-review__content\"><span class=\"medical-review__label\">Medisch gecontroleerd\n        <\/span><h2 id=\"medical-review-title\">Medisch gecontroleerd door drs. Elnaz Alagha\n        <\/h2><p>De medische informatie op deze pagina is gecontroleerd door\n            <a href=\"https:\/\/aeprilclinics.nl\/en\/doctor-elnaz-alagha\/\">drs. Elnaz Alagha\n            <\/a>,\n            BIG-geregistreerd cosmetisch arts, eigenaresse en medisch\n            directrice van Aepril Cosmetic Clinics.\n        <\/p><p>Drs. Elnaz Alagha beoordeelt de informatie op deze pagina op\n            medische juistheid, actualiteit en wetenschappelijke onderbouwing.\n            De inhoud wordt periodiek herzien aan de hand van relevante\n            medische inzichten en geldende kwaliteitskaders binnen de\n            cosmetische geneeskunde.\n        <\/p><div class=\"medical-review__specialisms\"><span class=\"medical-review__specialisms-title\">Specialisaties\n            <\/span><ul class=\"medical-review__specialisms-list\"><li><a href=\"https:\/\/aeprilclinics.nl\/en\/botox\/\">Botulinetoxine\n                    <\/a><\/li><li><a href=\"https:\/\/aeprilclinics.nl\/en\/fillers\/\">Fillers\n                    <\/a><\/li><li><a href=\"https:\/\/aeprilclinics.nl\/en\/skin-improvement\/\">Skinboosters\n                    <\/a><\/li><li><a href=\"https:\/\/aeprilclinics.nl\/en\/skin-improvement\/\">Biostimulatoren\n                    <\/a><\/li><li><a href=\"https:\/\/aeprilclinics.nl\/en\/medical-weight-loss-with-injections\/\">Medisch afvallen\n                    <\/a><\/li><\/ul><\/div><div class=\"medical-review__meta\"><div class=\"medical-review__meta-item\"><span class=\"medical-review__icon\" aria-hidden=\"true\"><svg viewbox=\"0 0 24 24\"><rect x=\"3\" y=\"5\" width=\"18\" height=\"16\" rx=\"2\"><\/rect><path d=\"M8 3v4\"><\/path><path d=\"M16 3v4\"><\/path><path d=\"M3 10h18\"><\/path><path d=\"M8 14h3v3H8z\"><\/path><\/svg><\/span><p><strong>Laatst medisch beoordeeld:<\/strong><br\/><time datetime=\"2026-07-26\">26 juli 2026\n                    <\/time><\/p><\/div><div class=\"medical-review__meta-item\"><span class=\"medical-review__icon\" aria-hidden=\"true\"><svg viewbox=\"0 0 24 24\"><path d=\"M12 3l7 3v5c0 4.8-2.9 8.7-7 10-4.1-1.3-7-5.2-7-10V6l7-3z\"><\/path><path d=\"M9 12l2 2 4-5\"><\/path><\/svg><\/span><p><strong>BIG-nummer:<\/strong><br\/>09932325201\n                <\/p><\/div><\/div><nav class=\"medical-review__links\" aria-label=\"Informatie over de medisch reviewer\"><a class=\"medical-review__button\" href=\"https:\/\/aeprilclinics.nl\/en\/doctor-elnaz-alagha\/\">Bekijk het profiel van drs. Elnaz Alagha\n            <\/a><a class=\"medical-review__text-link\" href=\"https:\/\/zoeken.bigregister.nl\/zorgverlener\/f35d0627-bb20-405c-8b19-e61f66d43c35\" target=\"_blank\" rel=\"noopener noreferrer\">Controleer de BIG-registratie\n            <\/a><a class=\"medical-review__text-link\" href=\"https:\/\/aeprilclinics.nl\/en\/medical-information\/\">Lees onze medische kwaliteitskaders\n            <\/a><\/nav><\/div><\/aside>\n\n<div class=\"wp-block-cover alignfull is-light wave\" style=\"margin-top:0;margin-bottom:0;padding-bottom:var(--wp--preset--spacing--30)\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-accent-background-color has-background-dim-100 has-background-dim\"><\/span><div class=\"wp-block-cover__inner-container has-global-padding is-layout-constrained wp-block-cover-is-layout-constrained\">\n<h2 class=\"wp-block-heading has-text-align-center\">Find out which polynucleotide is right for you<\/h2>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Are you unsure whether to choose Rejuran or PolyPhil? During a no-obligation consultation, our doctors will examine your skin, discuss your goals, and recommend the treatment that\u2019s best for you. You\u2019re welcome to visit Aepril Clinics in <a href=\"https:\/\/aeprilclinics.nl\/en\/clinic-utrecht\/\" type=\"page\" id=\"3390\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-base-color\">Utrecht<\/mark><\/a> or <a href=\"https:\/\/aeprilclinics.nl\/en\/clinic-hengelo\/\" type=\"page\" id=\"3336\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-base-color\">Hengelo<\/mark><\/a>.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-0aa01211 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-base-color has-accent-3-background-color has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/aeprilclinics.nl\/en\/book-free-consultation\/\">make appointment<\/a><\/div>\n<\/div>\n<\/div><\/div>\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Polynucleotides, also known as Salmon DNA, have become one of the most sought-after treatments in recent years for skin that has started to look thinner, drier, or more tired. If you look into them further, you\u2019ll quickly come across two&#8230;<\/p>\n","protected":false},"author":14,"featured_media":5518,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[215],"tags":[],"class_list":["post-25301","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-skin-improvement"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Rejuran vs. PolyPhil: Which One Do We Use and Why? - Aepril Clinics<\/title>\n<meta name=\"description\" content=\"Rejuran or PolyPhil? Read about the differences and how the doctors at Aepril Clinics in Utrecht and Hengelo choose between these polynucleotides.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/aeprilclinics.nl\/en\/2026\/11\/05\/rejuran-vs-polyphil-which-one-do-we-use-and-why\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Rejuran vs. PolyPhil: Which One Do We Use and Why? - Aepril Clinics\" \/>\n<meta property=\"og:description\" content=\"Rejuran or PolyPhil? 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